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The effects of L-AP4 and L-serine-O-phosphate on inhibition in primary somatosensory cortex of the adult rat in vivo
journal contribution
posted on 2023-06-09, 01:37 authored by Huimin Wan, P M B CahusacThe effects of two iontophoretically applied Group III mGluR agonists were studied on the inhibition in neocortex produced by natural stimulation of vibrissae. The agonists L-AP4 and L-serine-O-phosphate (L-SOP) were shown to produce qualitatively similar effects on the inhibition. Forty-four percent of neurones (total n = 57) displayed disinhibition during application of the agonists. The disinhibitory effects often outlasted the offset of the agonist application by at least 10 min. Concurrent application of the mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine ((+)-MCPG) appeared to reverse the disinhibitory effects of L-AP4 and L-SOP in 3 out of 5 neurones tested. However (+)-MCPG itself was found to have disinhibitory effects in some neurones. Some neurones (n = 7) showed increases in inhibition during either L-AP4 or L-SOP application. These appeared most pronounced in those neurones where the initial (pre-drug) inhibition was minimal, perhaps suggesting that the agonists were disinhibiting a local disinhibition. The data obtained in the experiments suggest that the disinhibitory effects are mediated by a heteroreceptor on inhibitory terminals, action at which depresses the release of inhibitory transmitter. The possible role of the modulation of inhibition by presynaptic mGluRs is discussed.
History
Publication status
- Published
File Version
- Published version
Journal
NeuropharmacologyISSN
0028-3908Publisher
ElsevierExternal DOI
Issue
8Volume
34Page range
1053-1062Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes