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The effects of symmetry on the dynamics of antigenic variation

journal contribution
posted on 2023-06-08, 15:53 authored by Konstantin BlyussKonstantin Blyuss
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of interactions between different antigenic variants. The results of this analysis are quite generic, and have wider implications for understanding the dynamics of immune escape of other parasites, as well as for the dynamics of multi-strain diseases.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Mathematical Biology

ISSN

0303-6812

Publisher

Springer Verlag

Issue

1-2

Volume

66

Page range

115-137

Department affiliated with

  • Mathematics Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-09-20

First Compliant Deposit (FCD) Date

2013-09-20

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