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The evolution of diverse biological responses to DNA damage: insights from yeast and p53

journal contribution
posted on 2023-06-07, 13:56 authored by G. M. Wahl, Antony CarrAntony Carr
The cellular response to ionizing radiation provides a conceptual framework for understanding how a yeast checkpoint system, designed to make binary decisions between arrest and cycling, evolved in a way as to allow reversible arrest, senescence or apoptosis in mammals. We propose that the diversity of responses to ionizing radiation in mammalian cells is possible because of the addition of a new regulatory control module involving the tumour-suppressor gene p53. We review the complex mechanisms controlling p53 activity and discuss how the p53 regulatory module enables cells to grow, arrest or die by integrating DNA damage checkpoint signals with the response to normal mitogenic signalling and the aberrant signalling engendered by oncogene activation.

History

Publication status

  • Published

Journal

Nature Cell Biology

ISSN

1465-7392

Volume

3

Article number

E277-E286

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-05-18

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