FKBP19_Mamm_Genome_Nov2005.pdf (849.41 kB)
The human FK506-binding proteins: characterization of human FKBP19
journal contributionposted on 2023-06-08, 00:32 authored by Stuart L Rulten, Ross A Kinloch, Hilda Tateossian, Colin Robinson, Lucy Gettins, John E Kay
Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway. There are distinct differences in tissue distribution and expression levels of each variant. In this article we describe the characterization of human FKBP19 (Entrez Gene ID: FKBP11), an FK506-binding protein predominantly expressed in vertebrate secretory tissues. The FKBP19 sequence comprises a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12. This domain binds FK506 weakly in vitro. FKBP19 mRNA is abundant in human pancreas and other secretory tissues and high levels of FKBP19 protein are detected in the acinar cells of mouse pancreas.
- Accepted version
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available