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The multifaceted role of lemur tyrosine kinase 3 in health and disease

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posted on 2023-06-10, 01:36 authored by Angeliki Ditsiou, Teresa Gagliano, Mark SamuelsMark Samuels, Viviana Vella, Christos Tolias, Georgios GiamasGeorgios Giamas
In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.

History

Publication status

  • Published

File Version

  • Published version

Journal

Open biology

ISSN

2046-2441

Publisher

The Royal Society

Issue

9

Volume

11

Page range

1-12

Event location

England

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-11-02

First Open Access (FOA) Date

2021-11-02

First Compliant Deposit (FCD) Date

2021-11-01

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