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The regulatory roles of phosphatases in cancer

journal contribution
posted on 2023-06-08, 21:28 authored by J Stebbing, L C Lit, H Zhang, R S Darrington, O Melaiu, B Rudraraju, Georgios GiamasGeorgios Giamas
The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.

History

Publication status

  • Published

Journal

Oncogene

ISSN

1476-5594

Publisher

Nature Publishing Group

Issue

8

Volume

33

Page range

939-953

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-07-07

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