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The role of Schizosaccharomyces pombe SUMO ligases in genome stability
journal contribution
posted on 2023-06-07, 14:54 authored by Felicity Watts, Andrew Skilton, J C Ho, Lara Katrina Boyd, M A Trickey, Lisa Gardner, Francois-Xavier OgiSUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins.
History
Publication status
- Published
Journal
Biochemical Society TransactionsISSN
0300-5127Publisher
Portland PressExternal DOI
Issue
6Volume
35Page range
1379-1384Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
GDSC260Full text available
- Yes
Peer reviewed?
- Yes