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The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier

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posted on 2023-06-10, 01:22 authored by Layla Burn, Nicholas Gutowski, Jacqueline Whatmore, Georgios GiamasGeorgios Giamas, Md Zahidul Islam Pranjol
Tumour metastasis to the brain is a complex process involving crosstalk between the circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which reside in the abluminal surface of the microvasculature of the BBB, are now known to play an essential role in tumour cell migration and invasion into the brain parenchyma. For instance, pro-inflammatory astrocyte secretions, including TNF-a, IL-6, CXCL10 as well as polyunsaturated fatty acids interact with circulating tumour cells to promote migration and proliferation. Additionally, astrocyte and tumour cell derived MMPs play a vital role in tumour cell invasion through the BBB. Understanding these complex interactions between tumour cells and astrocytes in the tumour microenvironment may contribute to the development of novel therapeutics for brain metastasis. Therefore, in this review, we present key interactions within the neurovascular unit of the BBB in the tumour microenvironment that significantly aids cancer metastasis, focusing particularly on astrocytes.

History

Publication status

  • Published

File Version

  • Published version

Journal

Frontiers in Bioscience-Landmark

ISSN

1093-9946

Publisher

Bioscience Research Institute

Issue

9

Volume

26

Page range

590-601

Event location

Singapore

Department affiliated with

  • Biochemistry Publications

Notes

Special Issue: The dynamic roles of glial and stromal cells in neurological diseases

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-10-11

First Open Access (FOA) Date

2021-10-11

First Compliant Deposit (FCD) Date

2021-10-11

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