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The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier
journal contribution
posted on 2023-06-10, 01:22 authored by Layla Burn, Nicholas Gutowski, Jacqueline Whatmore, Georgios GiamasGeorgios Giamas, Md Zahidul Islam PranjolTumour metastasis to the brain is a complex process involving crosstalk between the circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which reside in the abluminal surface of the microvasculature of the BBB, are now known to play an essential role in tumour cell migration and invasion into the brain parenchyma. For instance, pro-inflammatory astrocyte secretions, including TNF-a, IL-6, CXCL10 as well as polyunsaturated fatty acids interact with circulating tumour cells to promote migration and proliferation. Additionally, astrocyte and tumour cell derived MMPs play a vital role in tumour cell invasion through the BBB. Understanding these complex interactions between tumour cells and astrocytes in the tumour microenvironment may contribute to the development of novel therapeutics for brain metastasis. Therefore, in this review, we present key interactions within the neurovascular unit of the BBB in the tumour microenvironment that significantly aids cancer metastasis, focusing particularly on astrocytes.
History
Publication status
- Published
File Version
- Published version
Journal
Frontiers in Bioscience-LandmarkISSN
1093-9946Publisher
Bioscience Research InstituteExternal DOI
Issue
9Volume
26Page range
590-601Event location
SingaporeDepartment affiliated with
- Biochemistry Publications
Notes
Special Issue: The dynamic roles of glial and stromal cells in neurological diseasesFull text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-10-11First Open Access (FOA) Date
2021-10-11First Compliant Deposit (FCD) Date
2021-10-11Usage metrics
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