File(s) not publicly available
The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men
journal contributionposted on 2023-06-07, 18:54 authored by E Walderhaug, A I Herman, A Magnusson, M J Morgan, N I Landrø
Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S ) allele of the 5-HTTLPR on impulsive response style. Individuals who had the S /S genotype were more impulsive than individuals with the L/S genotype. Participants with the L/S genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently, and additively, associated with elevated impulsive response style in Caucasian men.
Department affiliated with
- Psychology Publications
NotesCollaborator and co-author
Full text available