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The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides
journal contribution
posted on 2023-06-07, 20:01 authored by John M Sanderson, P Singh, Colin W G Fishwick, John B C FindlayThe synthesis and reactivity of fully protected thioamide analogues of asparagine and glutamine are described. A key feature of the synthetic strategies employed was the ability to perform selective thiations on multiple carbonyl-containing substrates. Also described are the preparations of thioamide derivatives of phenylalanine. The utility of these amino acid derivatives for solid-phase peptide synthesis is discussed.
History
Publication status
- Published
Journal
Journal of the Chemical Society, Perkin Transactions 1ISSN
0300-922XPublisher
RSC PublishingExternal DOI
Volume
19Page range
3227 - 3231ISBN
1470-4358Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes