The Weak Gravity Conjecture states that in any consistent theory of quantum gravity in the landscape of string theory, the repulsive force mediated by a U(1) gauge field must be stronger than the attractive force of gravity. In this work, we calculate quantum gravitational corrections to the charge-to-mass ratio of extremal Reissner-Nordström black holes, using the Vilkovisky-deWitt unique effective action approach, since this ratio provides a discriminant to select low-energy effective theories of quantum gravity that fulfill the conjecture. We find that depending on the values of the Wilson coefficients of the effective action, some UV complete theories may fulfill the conjecture, while others may not.