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To live or to die: a matter of processing damaged DNA termini in neurons
journal contribution
posted on 2023-06-07, 21:48 authored by Sherif El-KhamisyDefects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed.
History
Publication status
- Published
Journal
EMBO Molecular MedicineISSN
17574676Publisher
Wiley-BlackwellExternal DOI
Issue
2Volume
3Page range
78-88Pages
78.0Series
EMBO Mol MedDepartment affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- No