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Translesion synthesis: Y-family polymerases and the polymerase switch
journal contribution
posted on 2023-06-07, 21:15 authored by Alan LehmannAlan Lehmann, Atsuko Niimi, Tomoo Ogi, Stephanie Brown, Simone Sabbioneda, Jonathan F Wing, Patricia L Kannouche, Catherine M GreenReplicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.
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Publication status
- Published
Journal
DNA RepairISSN
1568-7864External DOI
Issue
7Volume
6Page range
891-899Pages
9.0Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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