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2020 - Ran et al - Nat Comms.pdf (4.62 MB)
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Type-specific dendritic integration in mouse retinal ganglion cells

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posted on 2023-06-07, 08:54 authored by Yanli Ran, Ziwei Huang, Thomas BadenThomas Baden, Timm Schubert, Harald Baayen, Philipp Berens, Katrin Franke, Thomas Euler
Neural computation relies on the integration of synaptic inputs across a neuron’s dendritic arbour. However, it is far from understood how different cell types tune this process to establish cell-type specific computations. Here, using two-photon imaging of dendritic Ca2+ signals, electrical recordings of somatic voltage and biophysical modelling, we demonstrate that four morphologically distinct types of mouse retinal ganglion cells with overlapping excitatory synaptic input (transient Off alpha, transient Off mini, sustained Off, and F-mini Off) exhibit type-specific dendritic integration profiles: in contrast to the other types, dendrites of transient Off alpha cells were spatially independent, with little receptive field overlap. The temporal correlation of dendritic signals varied also extensively, with the highest and lowest correlation in transient Off mini and transient Off alpha cells, respectively. We show that differences between cell types can likely be explained by differences in backpropagation efficiency, arising from the specific combinations of dendritic morphology and ion channel densities.


Anisotropic retinal circuits for processing of colour and space in nature - Lister Institute Research Prize; G2503; LISTER INSTITUTE

Philip Leverhulme Prize - Biological Sciences; G2276; LEVERHULME TRUST; PLP-2017-005

A window into the fly brain: “dual imaging” of neural circuits involved in locomotor behaviour in Drosophila; G2180; MRC-MEDICAL RESEARCH COUNCIL

NeuroVisEco - Zebrafish vision in its natural context: from natural scenes through retinal and central processing to behaviour; G1871; EUROPEAN UNION; 677687

Anisotropic retinal circuits for processing of colour and space in nature; G2397; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/R014817/1

Optical Electrophysiology: Establishing fluorescence voltage imaging capability at Sussex Neuroscience; G2018; MRC-MEDICAL RESEARCH COUNCIL


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