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UVB and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UVB
journal contributionposted on 2023-06-07, 15:10 authored by Claudia Kerzendorfer, Mark O'DriscollMark O'Driscoll
The incidence of sunlight-induced skin cancer is increasing. Mouse studies indicate that caffeine, administered orally or topically, promotes apoptosis of UVB-irradiated keratinocytes. In this issue, Heffernan and colleagues identify the pathway targeted by caffeine and suggest that inhibition of this DNA damage response may offer a viable therapeutic option for nonmelanoma skin cancer. This potentially represents an important protective or therapeutic option from the most unlikely of sources: your daily coffee.
JournalJournal of Investigative Dermatology
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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