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X-Ray Diffraction Studies of Amyloid Structure
journal contributionposted on 2023-06-07, 22:33 authored by O Sumner Makin, Louise SerpellLouise Serpell
Elucidation of the underlying core structure of amyloid fibrils is essential for understanding the mechanism by which amyloid fibrils are formed and deposited. Conventional methods of X-ray crystallography and NMR cannot be used, since the fibers are insoluble and heterogeneous. X-ray fiber diffraction is one method that has been successfully used to examine the structure of these insoluble fibers. The procedure involves the formation of suitable, ordered amyloid fibrils and characterization (by electron microscopy), partial alignment of fibers, X-ray data collection, data analysis, and finally, model building.
JournalMethods in Molecular Biology
Department affiliated with
- Biochemistry Publications
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