Dr John Walshe and the treatment of Wilson's disease

Treatment of Wilson’s disease was transformed in the 20th century by the introduction of four drugs, which could be administered orally: D-penicillamine, triethylenetetramine (trientine) dihydrochloride, zinc acetate and ammonium tetrathiomolybdate. Three of these four oral treatments – D-penicillamine, trientine and tetrathiomolybdate – owe their provenance to the diligence, perspicacity and intuition of the English physician, Dr John Walshe.