University of Sussex
Dr Greg Scutt Gene multimorbidity abstract FINAL.pdf (18.56 kB)

Association of a regulatory anti-oxidant and drug-metabolising gene with multi-morbidity and adverse drug reactions in older adults

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posted on 2023-06-09, 14:19 authored by Chakravarthi RajkumarChakravarthi Rajkumar, Khalid Mustafa AliKhalid Mustafa Ali, Nikesh Parekh
Introduction Multimorbidity and adverse drug reactions (ADR) are problems associated with ageing populations. Exploring underlying genetic predispositions might help to risk-stratify patients for early intervention. The nuclear factor erythroid 2-like 2 (Nrf2) protein regulates antioxidant and de-toxifying effectors in the cell. Nrf2 expression declines with age, potentially increasing vulnerability to multimorbidity and ADR. We hypothesise that single nucleotide polymorphisms (SNPs) at 3 loci in the Nrf2 gene are associated with multimorbidity and ADR in older adults. Methods One-hundred and twenty-seven patients were recruited from a sub-population of the PRIME study (a multicentre prospective cohort study that followed older adults over 8-weeks post-discharge to determine ADR status). Donated genetic material was sequenced to determine genotype at 3 loci: rs6721961, rs35652124 and rs6706649 and then analysed for association with ADR (Naranjo Algorithm), multimorbidity (?3 conditions defined by the Charlson Index (CI)). Results One-hundred and twelve patients (mean age 76.6±7.3 years, 55.4% female) were successfully genotyped. In patients aged 65-79, those with the rs35652124 A allele showed increased odds of having ?3 co-morbidities (OR 9.03 95%CI 1.16-70.2, p=0.0127). Individuals with the CGG haplotype in this age-group showed reduced odds of multimorbidity (OR 0.11, 95% CI 0.01-0.86, p=0.001). No association between Nrf2 geno/haplotype and ADR was identified. Conclusions Polymorphisms in the Nrf2 gene are associated with multimorbidity, but not ADR, in older adults.


Publication status

  • Published

File Version

  • Accepted version

Presentation Type

  • speech

Event name

14th International Congress of the European Geriatric Medicine Society: Advancing Geriatric Medicine in a Modern World

Event location

Berlin, Germany

Event type


Event date

10th - 12th October 2018

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

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