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Compounds which potentiate the AMPA receptor and uses thereof in medicine
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posted on 2023-06-07, 23:21 authored by Nicolas Bertheleme, Wai Ngor Chan, Jacqueline Sandra Scott, Simon E WardCompounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
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2012-02-06Usage metrics
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