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Preparation of tricyclic compounds as CFTR channel inhibitors for treating polycystic kidney disease and diarrhea
standardposted on 2023-06-08, 20:50 authored by Mahbub Ahmed, Alexander Ashall-Kelly, Graham Charles Bloomfield, Louisa Gueritz, Jeffrey McKenna, Joseph McKenna, Simon Mutton, Rakesh Parmar, Jon Sheperd, Paul Wright
The present invention provides a CFTR inhibitor of formula (I) or a pharmaceutically acceptable salt thereof; and its therapeutic uses, e.g. in the treatment of diarrhea. The present invention further provides a combination of pharmacological active agents and a pharmaceutical composition.
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