Implications of long tails in the distribution of mutant effects
journal contributionposted on 2023-06-07, 13:47 authored by David Waxman, J. Feng
Long-tailed distributions possess an in nite variance, yet a nite sample that is drawn from such a distribution has a nite variance. In this work we consider a model of a population subject to mutation, selection and drift. We investigate the implications of a long-tailed distribution of mutant allelic e¤ects on the distribution of genotypic e¤ects in a model with a continuum of allelic e¤ects. While the analysis is confined to asexual populations, it does also have implications for sexual populations. We obtain analytical results for a selectively neutral population as well as one subject to selection. We supplement these analytical results with numerical simulations, to take into account genetic drift. We nd that a long-tailed distribution of mutant e¤ects may a¤ect both the equilibrium and the evolutionary adaptive behaviour of a population.
JournalPhysica D: Nonlinear Phenomena
Department affiliated with
- Biology and Environmental Science Publications
Full text available